In the planning of a clinical trial, calculating the sample size is a central step with far-reaching consequences. Evaluating different methods and comparing the sensitivity of the sample size with the assumptions is complex and time-consuming. This is where the R package sse: Sample Size Estimation steps in. sse allows you to calculate the sample size of your clinical research project for multiple scenarios. This framework for complex study designs allows statisticians and researchers to efficiently estimate the sample size using both existing power-calculation functions in R and resampling methods.